Precision medicine is an emerging approach for disease prevention and treatment that takes into account people’s individual variations in genes, environment, and lifestyle. This concept will generate the scientific evidence needed to move the concept of precision medicine into clinical practice. On the other hand, translational bioinformatics has rapidly evolved from an emerging research field into a complex multidisciplinary area that intersects biomedical research, informatics and clinical research. Translational Bioinformatics focus on the development of storage, analytic, and interpretive methods to optimize the transformation of increasingly voluminous clinical and bio-molecular data into proactive, predictive, preventive and participatory health. The clinical research program at the Taipei Medical University (TMU) is pioneering precision medicine for cancer treatment and, in collaboration with associated hospitals, aims to implement targeted therapies that are based on tumor genome profiling and on the Avatar mouse response to candidate drugs. The aim of this project is to intensify efforts to apply precision medicine to cancer. Innovative technique for long term use drugs and to quantify cancers risk, to explore drug repositioning and cancer comorbidities and Probability-based clinical decision systems. To translate the knowledge from cancer genome and bioinformatics. With the advancement in the Information Technologies, we need to provide efficient and better quality of care.